Telephonefaxe-mail moc. All rights reserved This article has been cited by other articles in PMC. The physical body weight, body mass index, total cholesterol, low density lipoprotein LDL cholesterol, high density lipoprotein HDL cholesterol, triglycerides, fasting blood sugar, creatinine and urea levels were determined before and following the administration of the ketogenic diet.
Changes in these parameters were monitored after eight, 16 and 24 weeks of treatment. From week 1 to week HDL cholesterol levels considerably increased The level of total cholesterol decreased, whereas LDL cholesterol levels decreased after treatment. The level of triglycerides decreased following 24 weeks of treatment significantly. The level of blood glucose decreased. The noticeable changes in the amount of urea and creatinine weren’t statistically significant.
It considerably reduced the physical body weight and body mass index of the patients. Furthermore, it decreased the amount of triglycerides, LDL cholesterol and blood sugar, and increased the amount of HDL cholesterol. Administering a ketogenic diet for a comparatively longer time period didn’t produce any significant unwanted effects in the patients. Therefore, today’s study confirms that it’s safe to employ a ketogenic diet for an extended time period than previously demonstrated.
Keywords: Diet, Ketosis, Obesity Obesity has turned into a serious chronic disease in both developing and developed countries. Furthermore, it is connected with a number of chronic diseases 1 – 4.
It’s estimated that in the usa alone approximatelypeople die every year from obesity-related diseases 56. Different options for reducing weight using reduced calorie and fat intake coupled with exercise have didn’t show sustained long-term effects 7 – 9.
Recent studies from various laboratories 1011including our very own 12have demonstrated a high fat diet abundant with polyunsaturated essential fatty acids ketogenic diet is fairly effective in reducing bodyweight and the chance factors for various chronic diseases. The ketogenic diet was originally introduced in In the dietary plan, the fat to carbohydrate ratio is While there is a significant reduction in the weight of obese patients who were on a ketogenic diet 12the reverse occurred when the dietary plan changed to one saturated in carbohydrates It must be noted that the idea that fat could be eaten ad libitum but still induce weight loss in obese subjects isn’t a recently available one 13 – Incomplete oxidation of essential fatty acids by the liver results in the accumulation of ketone bodies in your body.
A ketogenic diet maintains the physical body in circumstances of ketosis, which is seen as a an elevation of D-b-hydroxybutyrate and acetoacetate. Mild ketosis is an all natural phenomenon occurring in humans during fasting and lactation 19 Postexercise ketosis is a well-known phenomenon in mammals. Although the majority of the noticeable changes in the physiological parameters induced following exercise revert back to their normal values rapidly, the amount of circulating ketone bodies increases for a couple hours after muscular activity ceases It’s been discovered that in trained individuals, a minimal blood ketone level protects against the development of hypoglycemia during prolonged intermittent exercise Furthermore, ketosis includes a significant influence on suppressing hunger.
It really is generally believed that high fat diets may result in the development of obesity and many other diseases such as for example coronary artery disease, cancer and diabetes. This view, however, is founded on studies completed in animals which were given a higher fat diet abundant with polyunsaturated essential fatty acids.
On the other hand, our laboratory has demonstrated a ketogenic diet modified the chance factors for cardiovascular disease in obese patients Although various short-term studies examining the result of a ketogenic diet in reducing the weight of obese patients have already been completed 10its long-term effects in obese subjects aren’t known Therefore, the objective of today’s study was to research the long-term ramifications of a ketogenic diet on obesity and obesity-associated risk factors in a sizable population of obese patients.
Your body mass index BMI of people was The mean age was The mean age, initial height, bMI and weight for all patients receive in Table 1. Fasting blood tests were completed for every one of the subjects.
Initially, all patients were put through liver and renal function tests, and glucose and lipid profiles, using fasting blood samples, and a complete blood count. Thereafter, fasting blood samples were tested for total cholesterol, high density lipoprotein HDL cholesterol, low density lipoprotein LDL cholesterol, triglycerides, blood sugar, urea and creatinine levels at the eighth, week 16th and 24th.
In addition, height and weight measurements, and blood circulation pressure were monitored at each visit.